Clostridium Difficile Symptoms The symptoms of C. Difficile colitis range between mild to severe. Watery diarrhea is the main symptom regardless of the severity of the infection, although it might not be present in every patient. Some individuals are carriers of the organism and don’t develop a dynamic infection. They might shed the organism and cause environmental contamination. Generally, gentle C. Diff infection may bring about: abdominal pain and cramping,bloating,nausea,vomiting,fatigue, andfever.The diarrhea might occur up to 10 to 15 times daily.The striatum is located in the mind, and is partially responsible for proper movement within the basal ganglia network. The striatum becomes severely compromised in Parkinson's disease due to neurite retraction from dopaminergic neurons situated in the substantia nigra. The data generated in this study show that when compared to GDNF, a neurotrophic factor currently in a Phase 2 clinical trial for Parkinson's disease, MANF had a significantly higher volume of distribution when delivered to the striatum. These email address details are component of on-going animal research to determine the greatest localization of delivering MANF to the brain in Parkinson's disease human clinical research.