health

New mRNA-based therapy acts against cancer stem cells

A gene therapy approach to preventing cancer metastases in prostate cancer or lung cancer appears to work better in research results and more resistant against a range of attempted mutations, as well as distinct cell populations and different cell types.

The pivotal results of this phase 2 randomized clinical trial were published today in The BMJ and provide strong evidence that the approach showed statistically significant benefit. If adopted it may provide a new scenario in cancer therapy, and inform the development and course of patients’ care.

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Rates of metastatic breast cancer ‘profits’ still matter less than drug costs

Comparing costs of laboratory testing using biopsied tissue sections vs. compared drug costs for patients with metastatic breast cancer, analysis found that comparing the passes-throughs based on published drug spending reveals a net value decrease.

Research from Beth Israel Deaconess Medical Center (BIDMC) submitted to JAMA Network Open seeks to better understand the priority given to breast cancer patients who need surgery and/or require biosimilars in order to reduce their risk of recurrence. The study was led by team members from BIDMC’s Louis Stokes Cancer Center, the Thomas Jefferson Vanderbilt-Ingram Cancer Center at Vanderbilt University School of Medicine (VUSM) and the Cancer Neonatal Program at CHOP (Colorado Springs). The team evaluated the harms and benefits of employing low cost tests for biomarkers that predict patient outcome. This hypothesis analysis is based upon dichotomous analysis of published costs and published drug spending.

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Observing opposing neuronal states in a global scan

News that one of the world’s most advanced brain research centres will serve all nations is spreading like wildfire across the internet in the past 24 hours.

Harvard brain scientists are launching a global probe in search of the ins-and-outs of each different method of categorizing images inside our brains and whether they correspond to any of the seven basic personality traits (fun-sensitive, openness-dependent, conscientious-focused, extroverted and conscientious-focused).

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Dementia patients could alter sleep behavior to improve cognition

Older people who are diagnosed with dementia have difficulty with tasks that require cognitive flexibility, such as remembering appointments to doctor visits and paying bills, according to new research published in the journal Neurology Open.

Researchers from the University of Birmingham studied four patients who met the criteria for a diagnosis of dementia. Individuals had a diagnosis of physical dementia and dementia based on the Alzheimer’s Disease Neuroimaging Index, which allows researchers to measure changes related to cognitive abilities and their related changes in brain activity since a patient first rediscovered independence in the 1980s. The three patients were randomly assigned to either a low-dose of intravenous immunoassay (IVI) to enhance insulin secretion to the brain or to receive room batwash for 12 hours per day. The IVI and room batwash treatment was given between November 2017 and October 2019.

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COVID-19 – CD victim dies at 28, at most|

A young man who died of COVID-19 at the age of 28 has been declared the third patient to have died of the disease after three elderly neighbours, a Bangladeshi man and a Namibian woman, authorities said on Tuesday.

The 23-year-old man was one of the first patients admitted to a private home in Nyabber borough, a government spokeswoman told Reuters.

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Science Blows Way to Stop the Spread of Flu from Within

Healthcare providers are seeking ways to prevent the spread of viruses within themselves, thanks to a new discovery by researchers at The University of Texas Health Science Center at Houston (UTHealth). The discovery could mark a significant step toward preventing the 2009 H1N1 influenza pandemic that left 83 people dead. By understanding how viruses migrate from one part of the human population to another, UTHealth scientists could potentially help combat future flu pandemics, said Jacob Grigg, PhD, assistant professor in the Department of Biomedical Sciences and the study’s principal investigator.

A report on the publication appeared today in the journal Cell Reports.

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